The NEIL2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NEIL2. This antibody recognizes Human, and Mouse antigen. The NEIL2 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates.
Subunit Structure: Binds EP300.
Similarity: The zinc-finger domain is important for DNA binding. Belongs to the FPG family